Tired of Having to Change Your Food Choices and Suffering all the Time Just to Lose a Few Pounds?
317 Peer-Reviewed Scientific Studies
Prove There Is a BETTER Way
Now You Can Use this Simple 24-hour Weight Loss Trick Below to Achieve 7x Faster Fat Loss WITHOUT Dieting or Changing The Foods You Eat Everyday…
On this very page you’ll finally have access to accurate, reliable, and NON-deceptive information about how to QUICKLY lose weight, WITHOUT having to change the foods you eat.
“This is why I reviewed 317 published, peer-reviewed scientific studies — so I could be 100% Confident when I tell you that the simple weight loss method I reveal on this page WILL help you lose weight, get rid of ugly body fat and naturally stimulate fat burning hormones in as little as 24 hours, all without sacrificing your metabolism or hard-earned muscle.”
My name is Brad Pilon, and I am going to share with you an easy-to-implement weight loss strategy specifically designed for men and women who want to lose fat without dieting, changing the foods they eat, or sacrificing their metabolism, muscle, or energy levels.
Listen, I am WELL aware of all the false and misleading weight loss products out there… Just like you I've paid good money for dozens of different diet books and workout programs only to be disappointed.
So believe me when I say I am confident that after reviewing all of the available scientific research, I can tell you what the 24-hour weight loss method below will help you…
- Lose weight
- Get rid of ugly body fat and
- Naturally stimulate fat burning hormones in as little as 24 hours
- All without sacrificing your metabolism or heard-earned muscle!
The 2000 Year Old Secret of Plato and Hippocrates That Can Make YOU Lean and Sexy
I know this sounds far-fetched which is why I've included the over 320 research papers you will see referenced at the end of this page that scientifically validate every single claim I just made.
Why am I telling you this? Simple - I do not want you to feel misled by anything I tell you.
I want to be completely upfront and honest with you and I will do everything I can to provide you with the information that you need to decide whether or not Eat Stop Eat is the right weight loss program for you.
The principles behind the Eat Stop Eat system have been around for millennia, and were praised by ancient philosophers like Plato and Hippocrates as the very best way to maintain your health and wellness. Yet, it has only been in the last 25 years that science has begun to support these ancient philosophers' theories.
I've used this research to design a system called Eat Stop Eat to help you lose weight without feeling deprived or going days on end barely eating.
And I've designed it to ensure that almost all of the weight you lose will come from your body fat!
Is This Common Weight-Loss Deception Silently Trapping Fat In Your Cells Each and Every Day?
"Eat Stop Eat does NOT involve eating complex combinations of special foods or complicated meal timing methods"
I understand this may seem a little confusing. After all, you've probably heard or even believed that you need to eat multiple small meals throughout the day in order to keep your metabolism "revving," and you're probably worried about things like 'starvation mode', which is the crazy idea that your metabolism will "slow to a halt" if you don't eat every couple hours…
However, the 24-hour weight loss method you’ll learn about on this page does NOT require you to eat frequent meals. And it doesn’t force you to eat specific foods or food combinations. In fact, you won’t even need to give up any of your favorite foods, snacks or treats! And as you’ll see shortly, you’ll never experience the mythical “starvation mode”, slowed metabolism, muscle loss or weight loss plateaus most complicated diet “gurus” try to scare you with…
Worse… The Weight Loss Industry & Packaged Food Companies Knowingly Spread This Lie To Get More Money From You…
Truth is, fancy diet schemes and complicated nutrition systems are total garbage…
In fact, they are purposefully misleading - all based on the principle that you must keep eating to lose weight.
This idea has never made any sense to me, yet the diet industry keeps on trying to convince you that in order to lose weight you must keep eating!…
After all, if you have to keep eating to lose weight, then there must be special ways to eat to lose fat. Special complicated ways.
Listen, the thought of eating more to lose weight is both silly and dangerous…
The idea that you can eat as much as you want and still lose weight is one of the key signs of a weight loss scam – yet it is also one of the most popular claims on the Internet!
"The idea that you can eat as much as you want and still lose weight is one of the key signs of a weight loss scam"
There are literally billions of dollars being spent every year on weight loss and diet books. It seems like each day a new book comes out telling you what you need to eat to start losing weight.
Recent projections suggest the diet marketing industry is worth anywhere between $20 billion and $60 billion in annual revenue. That's almost DOUBLE Mark Zuckerberg's reported total net worth!
Peer-Reviewed Research Proves That Using This 2000 Year Old Nutrition Secret Can Boost Your Fat-Burning by 700%
Indisputably, the most important hormone in your body when it comes to weight loss is something called Human Growth Hormone…
An increase in Growth Hormone, along with a steady decrease in Insulin is the 'Perfect Storm' for burning body fat at record speed.
In fact a recent paper published in The American Journal of Physiology - Endocrinology and Metabolism has reported that the unique technique you'll discover below can result in a 700% increase in fat burning.
Think about this for a moment – this isn't some wild claim made by some actor pretending to be a doctor – it's the exact finding from a peer-reviewed research paper that was specifically studying the EXACT eating recommendations found within Eat Stop Eat…
And this is just one of the hundreds of studies that support this style of eating as an effective way to increase fat burning.
In fact, after trying this simple weight loss strategy, I'm willing to bet that you will tell your friends and family that it is the easiest to understand, most flexible diet plan you've ever seen.
And I'm willing to bet you also say it's the most effortless fat loss you've ever experienced.
Why The World’s Most Popular Diet Rules Have Caused You Unnecessary Suffering and Weight Loss Failure
If you're anything like the millions of other people out there who have ever experienced the pain and frustration that comes from trying to lose weight, you know that the traditional way to diet is not fun…
It involves months of scrutinizing every single piece of food you put in your mouth, and never being able to eat any of the foods you love. Sometimes you get to save up all your favorite foods for the occasional cheat day (if you're lucky) and ultimately almost every diet becomes a slow inevitable march towards failure. Just about every diet can make you feel miserable.
I've never met a single person who actually enjoys constantly obsessing over food or pretending that being irritable and cranky is just a sign of their awesome 'dedication' to their diet. This isn't dedication; it's a obsessive form of self-punishment that needs to just go away.
Dieting every day and THINKING about dieting every day can drain the life right out of you. This isn't because you're weak, or because you're not dedicated enough - it's like this for EVERYONE…
The Eat Stop Eat solution I'm about to cover in detail completely ELIMINATES this "diet drudgery"…
How Being A Nerd Helped Me Discover The EASIEST Weight Loss System In The World—WITHOUT Changing The Delicious Foods We All Love To Eat Every Day
I have spent my entire life studying nutrition and weight loss, and I have taken a very unusual path that ultimately led me to discover the simple weight loss system that has been hiding in front of our noses for over 2000 years
For starters, I have an honors degree in nutrition. So I understand the classic academic approach to how we should eat. I spent four years of university studying all of the typical 'eat less calories than you burn' type of stuff you need to know to become a dietitian.
Now here's where it gets interesting, right after university, I started doing research for the weight loss industry…
From managing the R&D department of a very successful sports supplement company to consulting start up companies, manufacturers and top fitness magazines, I have seen the inner working of the industry that only a privileged few have ever seen.
Here’s the REAL Truth About the Supposed ‘Weight Loss in a Bottle':
There isn't a pill in the world that can
burn HALF as much fat as the simple
24-hour weight loss trick found below… Period.
During my time in the industry part of my responsibilities included traveling the world learning about potential cures for obesity (weight loss supplements are big money, so the first company to come out with a new ingredient that actually worked would be making billions).
Travelling to China, Germany, Scotland, England and all over North America, I have had the privilege of meeting some of the world's greatest minds in nutrition and weight loss.
Not only have I been lucky enough to travel the world but I have also had unlimited access to state of the art exercise physiology equipment, the kind of equipment that would make many University laboratories green with envy.
With this equipment I was able to conduct multiple body composition tests on numerous athletes and top level bodybuilders and monitor them while they dieted and tried new experimental weight loss programs.
This discovery the laboratory tested cutting edge
science that helps athletes and top level
bodybuilders become incredibly lean, muscular,
In fact, it was these experiments that ultimately led me to leave the industry and my career so that I could pursue graduate studies in human biology and nutritional sciences.
Many of the experiments I conducted had results that were VERY different from what I expected, and I soon realized that if I were to truly understand nutrition's role in weight loss, then I would have to start from the very beginning and study what happens to the body when it goes without ANY food.
Believe it or not, the system I developed and cover in detail below, called Eat Stop Eat, is actually the direct result of all of the research and scientific reviews I completed in graduate school on the benefits of fasting for weight loss and for health.
That's right, my research was on 'The Metabolic Effects of Short Periods of Fasting in Humans and its Potential Application in Weight Loss', so in essence when you read Eat Stop Eat what you are really seeing is an easy-to-read version of my graduate education!
That was over 7 years ago, and since then Eat Stop Eat has helped 21,000 of people lose weight.
In fact, at the bottom of this page, I share with you a some of the over 300 reviews Eat Stop Eat has received on the independent book review site, Goodreads. While I'm sure there's no such thing as 'typical' weight loss results, the thing I love is how easily these people were able to incorporate Eat Stop Eat and exercise into their lifestyles.
Now You Have Access To A 24 Hour
Diet Shortcut That ANYBODY Can
Use To Get A Lean, Toned &
Athletic Looking Body…
Aside from being a nutrition professional, I am also an athlete. I have competed in (and won) amateur bodybuilding contests and powerlifting meets.
In fact, I have been a fitness junkie my whole life. My quest for answers began with my love of muscle. so in a weird sort of way my love of Bodybuilding is what led me to Eat Stop Eat. So making sure you keep your hard-earned muscle is just as important to me as making sure you can easily get rid of your extra belly fat.
After all, what's the point of losing body fat if all you've got left is skin and bone?
Eat Stop Eat is the EASIEST nutrition plan to help you have
the lean, toned body you so deeply desire—ALL while exercising
and dieting LESS.
Need Proof it Works?
Just look at my pictures below and you’ll see that I've spent the last 8 years using Eat Stop Eat to add significant amounts of lean muscle while losing fat at the SAME time… And I have the DEXA tests to prove it!
The pictures above are of me. The first one was taken more than 6 years ago. It was after 5 months of dieting for my first bodybuilding show. I planned my meals, ate well over 200 grams of protein per day, did cardio in the morning, weights at lunch, then cardio again at night.
I thought this was 'as good as it gets'. I believed that hard work, dedication, sacrifice and suffering were the ingredients needed to have the body I wanted.
The second picture was taken three years later, after three years of following the Eat Stop Eat Diet Plan. No more suffering and sacrifice.
The third picture is 8 years later (March of 2014). In the last 8 years I've realized that Eat Stop Eat is all I need to stay lean. No more obsessive compulsive dieting, no more mega-dosing protein and no more falling for every single diet scam I see on the internet.
Think You Have a "Slow Metabolism” or "Terrible Genetics"?
Eat Stop Eat Automatically BUSTS
Through Any Weight Loss Plateau
Eat Stop Eat is not about only eating certain amounts of food in certain food groups, nor does it push any special 'rules' on you about what you can and can't eat. It doesn't involve blocking the absorption of fat or calories, and it certainly doesn't involve rubbing fat loss creams or lotions on your body.
What it does do is give you the simplest most sustainable way I have ever used to lose weight, along with all of the scientific facts that support this statement.
This is strategic weight loss at it's finest - All of the hormone-manipulating, calorie-cycling, weight-loss-causing techniques you could imagine, rolled into one simple to follow, easy-to-start diet plan, that will work for you even if you have a slow metabolism or 'terrible genetics'.
Please let me be explicitly clear about one thing - Eat Stop Eat isn't just a diet - it's also the leading resource on the benefits of Intermittent Fasting for weight loss AND health…
First published in 2007 Eat Stop Eat has long been considered the 'go-to' "Fasting" Diet - Plus I update it almost every year to make sure that it is always on the cutting edge of weight loss research.
[…All Eat Stop Eat customers get every update for free…]
I don't think I can be any more transparent than to tell you this is a detailed book on the science behind intermittent fasting and fasting for weight loss, and the specific style of intermittent fasting that makes the Eat Stop Eat approach so unique, and so effective for both men and women.
You simply will NOT find a better collection of intermittent fasting research in any book, anywhere on the Internet. And let's be honest, there are good intermittent fasting approaches and then there are bad intermittent fasting approaches – With Eat Stop Eat you will find the style that best suits you.
Unlike other diet books Eat Stop Eat is not complicated, and it is not hard to understand. It is not full of filler, it is not 300 pages long and it is not 10 pages of diet advice and 200 pages of recipes. What Eat Stop Eat does have is a simple and effective way to lose body fat that is easier to stay on than anything you have ever tried before!
Introducing Eat Stop Eat:
The One and Only 24-hour Weight Loss
System That Gives You 7X GREATER Fat
Loss, Without Dieting or Giving Up Your
Favorite Comfort Foods
Here are some of the unique benefits — backed by published scientific research — that Eat Stop Eat offers you:
You don't have to worry about food all day. Eating every three hours, cycling your protein and your carbs, measuring your glycemic index, I don't think any of these things are needed for solid long lasting weight loss. With Eat Stop Eat you can forget about all of these obsessive compulsive eating habits.
Your metabolism will not slow down and you will not go into "starvation mode". With Eat Stop Eat you will clearly see the research behind why short periods of fasting will not cause you to go into starvation mode. Your metabolism will stay just as high as it ever was (In fact, some research suggests it may even go higher!)
Your Testosterone levels will not plummet. Short period of fasting for weight loss will not cause your testosterone levels to plummet, in fact, they are typically HIGHEST when you are fasting (unless you are a mouse). Truthfully, losing excess weight could be one of the best things any man (or woman) could do maintain healthy levels of testosterone
You will not get light-headed and cranky! It is actually a myth that not eating causes you to become cranky or light headed. From my experience it is actually a mental 'addiction' to eating that makes most people get cranky when they don't eat. Eat Stop Eat can help you to break the 'food addiction' that causes this reaction.
You don't have to avoid going to restaurants with your friends. Eat Stop Eat is flexible. Spending months hiding from your friends because you are on a restrictive diet is a thing of the past. Now you can enjoy the freedom to live normally (and still lose weight).
You will save money. Eat Stop Eat won't ask you to start drinking organic raw goats milk or non-pasteurized rice milk or any other expensive food that you really don't like. With Eat Stop Eat you will learn why you don't have to spend any extra money on "special foods" if you want to lose weight.
You will boost your body fat burning hormones. With Eat Stop Eat you will reap the benefits of naturally increasing the exact same hormones that celebrities are paying thousands of dollars for in an attempt to stay lean, muscular and young looking.
You will not have to take any weird supplements or eat special foods. Let's face it. A good nutrition program should not ever have to rely on supplements to help you lose weight.
You will still have great workouts. Think not eating for a couple hours is going to ruin your workout? Think again. You can still have amazing body fat burning and muscle building workouts while following Eat Stop Eat.
You will not lose ANY of your hard earned muscle. Eat Stop Eat will show you the scientific facts behind why a lot of what you are told about dieting and muscle loss is nothing more than diet industry scare tactics.
You will lose weight, and this weight will be all body fat. With the Eat Stop Eat program, weight loss is steady and consistent, and the weight you will lose will be body fat.
You don't have to avoid carbs, or fats. Forget about eating canned tuna and low fat cottage cheese for days on end, Eat Stop Eat was designed to work in the real world, so you can eat real food and still lose weight.
You don't have to eat mega-doses of protein every day. Do you think you need to eat 50 grams of protein every 2-3 hours in order to lose weight? Well think again. With Eat Stop Eat you'll learn the real truth behind protein, muscle mass and dieting. Goodbye expensive gross protein shakes.
You will not have to take any weird cleansing products or laxatives. Eat Stop Eat is an advanced fasting diet that is based on real world science. There are no weird potions or laxatives involved.
You can follow the diet you like best. With Eat Stop Eat you can follow any style of eating you like, after all, Eat Stop Eat doesn't tell you what you can and can't eat, that's all up to you.
You will be productive. With Eat Stop Eat, you won't go into a super low productive funk like what happens with some traditional diets. In fact, many people have told me that they are their absolute most productive on their fasting days!
You will have energy. With Eat Stop Eat you will not feel tired, cranky or lethargic. In fact, I'm guessing you will feel energized and alert.
And most importantly, you will not waste any of your precious time!
I have no doubt that once you realize the ease and the simplicity of the Eat Stop Eat lifestyle you will be absolutely amazed. You may even think that I am lying, but it's all true, and it is all backed by solid scientific research.
When I finished writing the first manuscript of Eat Stop Eat, I handed it to one of my friends who has tried just about every popular diet on the market. When she finished Reading Eat Stop Eat, she put the book down, looked up at me and said "Brad, if it's really this easy, I'm going to be very pissed off!"…
Well it is just that easy, and it does make that much sense.
But I do understand why you are skeptical – after all, a recent survey suggested that more than 40% of weight loss advertisements make at least one claim that is almost certainly false and misleading – That's almost half the ads you see. So I understand your hesitation and want to make sure that you know EXACTLY what Eat Stop Eat has to offer you…
Sound TOO Easy?
Let Me ELIMINATE Your Skepticism To Prove
It Will Work For You Starting TODAY
Listen: Eat Stop Eat isn't a fad diet promising unbelievable or dramatic weight loss — just rapid, permanent and noticeable weight loss — so I don't need to entice you with a bunch of 'empty promises'. It's a sensible weight loss program backed by credible, accurate and reliable scientific research.
And because I have refused expensive publishing deals for the English version of Eat Stop Eat, I'm able to offer it to you at almost half-off the regular price today. I truly believe that you and every man or woman who wants to lose weight owes it to yourself to read this book today.
Heck, I'm so confident that Eat Stop Eat is the only weight loss solution you will ever need, that I'm even willing to let you read it absolutely FREE of charge for 3 days so you can see for yourself how easy and powerful it is. If you'd prefer that option just look below the Yellow button further down the page…
You'll have immediate access the minute you make the savvy decision to get started today.
Yet… YOU DO NOT HAVE TO DECIDE TODAY…
Even if you keep the book longer than three days, you STILL have a full 60 days to enjoy the weight loss results of the Eat Stop Eat lifestyle before you decide. You see, if you decide at anytime before the end of 60 days that you are not experiencing the same effortless weight loss as over 21,000 other Eat Stop Eat fans, just let me know and I’ll happily refund every penny of your purchase.
Eat Stop Eat OPTIMIZED
By far, the most common reason for failing on a diet is feeling overwhelmed and just not even getting started…
Eat Stop Eat OPTIMIZED is simply the quickest, easiest, most done for you day-by-day, real life application of the principles in ESE.
I've been living the ESE lifestyle for years. And I'm constantly tweaking and improving the way I apply it in my busy life. I'm married with 2 kids, I have a hectic travel, interview and writing schedule, and I run 2 successful businesses. Through all that, I've meticulously recorded everything and boiled it down into this very personal, very practical and absolutely invaluable done-for-you guide to losing weight quickly and permanently, no matter how busy you get.
Inside ESE OPTIMIZED you'll discover…
- Exactly how many calories I eat (and even pictures of my meals)
- The ONLY supplements you should take, and why
- Why you must NEVER snack on protein (despite what you've heard)
- The ONE exercise that is MORE important than weight training OR cardio
- Why you should never exercise while you're fasted
- And all the rest of the day to day tricks I used to get in the best shape of my life without "dieting" and while exercising half as much as I used to…
Eat Stop Eat Quick Start Guide
Have you ever skipped the complicated instructions when setting up some new software on your computer, and then regretted it? That's me… I always want to skip ahead and just get started, which is why I created the Quick Start Guide
When you make this wise decision, you will…
- Feel the weight of obsessive and restrictive dieting lifted from your shoulders
- Drop ALL the weight you desire in only 24 hours
- Wake up free of daily diet restrictions and able to eat your favorite foods
- Avoid the "Standard American Diet — SAD — that AGES YOU FASTER and start eating in a way that's proven to defy the aging process
- And Much Much More!
Click The "Buy Now" Button To Receive Your
Limited Time New 5th Edition Price Of Just $20…
PLUS All The Bonuses (Worth Over $97!)
Remember, everything you've been doing up until now has not worked and now you know why. Continuing to follow fad diets full of misleading claims will only lead you to even more frustration and greater despair as the weeks pass by and your struggle with your stalled weight loss efforts.
This can continue to negatively affect everything from your relationships with your friends, your quick temper with your family and loved ones, your satisfaction with your career and even all the way down to the clothes you wear.
None of this is what I want for you and I know this is not what you desire for yourself.
I honestly believe that in 5 years time this is how everyone will be eating. But why wait 5 years? Like I said, by then everyone will be following Eat Stop Eat. If this sounds like the solution you've been looking for - the type of solution that could help you attain long lasting weight loss results - then I recommend clicking the add to cart below and get reading!
Once you have read this book, I guarantee you will never want to, or NEED to pick up another nutrition or diet book ever again!
Brad Pilon MS
Author, Eat Stop Eat
P.S. Below are some of the over 300 reviews Eat Stop Eat has received on the independent book review site, Goodreads. While I'm sure there's no such thing as 'typical' weight loss results, the thing I love is how easily these people were able to incorporate Eat Stop Eat and exercise into their lifestyles.
Scroll to Browse a Selection of Over 300 Independent Reviews From the Goodreads website
Goodreads Reviews for Eat Stop Eat
P.P.S. Eat Stop Eat is just a little over 200 pages long – It is simple and concise and will probably only take you one evening to read. If you want to be blinded by complex and confusing pseudo-scientific explanations, misleading metabolism marketing and 'Eat this not that' lists of foods then this is NOT the book for you.
However, if you are looking for the very best resource on fasting for weight loss and are willing to accept the possibility of a very simple and incredibly effective method of shedding body fat then Eat Stop Eat is definitely the book for you.
P.P.P.S. As you know, you can try Eat Stop Eat FREE for 3 days. Yet even if you choose to keep the book, and decide any time within the next 60 days that it is not what you were looking for, or that it just does not work for you the way it has for tens of thousands of other savvy folks around the world, please just let me know and I will happily return every penny of your investment.
If You Still Have Questions, Chances Are Someone Else Has Also Asked Me Something Similar. Here Are a Few of The Most Common Questions I Get About Eat Stop Eat…
Q: I want to lose fat and gain muscle. Can I do both with Eat Stop Eat?
A: Absolutely. In Eat Stop Eat I outline exactly how you can build muscle while also losing body fat. You can check out the chapter 'Fasting and your muscle mass' for more information.
Q: I'm really enjoying the weight loss results I'm getting from Eat Stop Eat, but I'd still like to clean up the way I eat even more, any tips?
A: With Eat Stop Eat you can incorporate any diet style you like. My personal opinion is that the general guideline of eating 'lean and green' with lots of fruits, vegetables, herbs and spices is an ideal complement to the Eat Stop Eat lifestyle, but you can incorporate any diet style you wish and still see fantastic results You can check out the chapter 'How to eat, Eat Stop Eat style' for more information.
Q: I've heard that women shouldn't follow diets that involve missing meals, is this true?
A: The Eat Stop Eat style of eating has helped thousands of women lose weight. In fact, there is an entire chapter in Eat Stop Eat devoted to helping women get the absolute best results possible from Eat Stop Eat, you can check out the chapter 'Fasting for women' for more information.
Q: Do you think the Eat Stop Eat lifestyle would be beneficial to someone who is simply trying to maintain his or her current weight?
A: Yes. Eat Stop Eat provides a simple way to lose weight, and to also maintain your weight. The trick is in the timing. You can check out the chapter 'How to keep it off' for more information on maintaining your weight with Eat Stop Eat.
Q: Can you guarantee that I will lose fat if I buy your book?
A: No. Eat Stop Eat does not have a weight loss guarantee. Any diet that does is scamming you. Any effective Weight loss program requires you to eat less and exercise more. when you purchase Eat Stop Eat what you get is a book outlining all the principles you need to be very successful at losing weight and keeping it off, but it's up to YOU to actually put these principles into action.
Q: Is this type of diet healthy in the long run?
A: According to the research, yes. Fasting initiates many health promoting pathways inside your body, including decreasing inflammation, activating autophagic pathways, and decreasing your body's total toxin load. For more information you can check out the chapters in 'The Health Benefits of Fasting' section of Eat Stop Eat.
Q: I really want to try this diet, but I'm worried that I'm too old. Is this program appropriate for someone my age (I'm 67 years young)?
A: Absolutely. Many of our best Eat Stop Eat transformations have come from people over the age of 50. As long as you have medical clearance to diet and exercise this program will work for you if followed correctly. When in doubt you can always check with your healthcare professional.
Q: I've read that high protein diets can help with weight loss. Can I eat a high protein diet while doing Eat Stop Eat?
A: Yes. With Eat Stop Eat HOW you eat is completely your choice. There are several published research studies suggesting that a higher amount of dietary protein might be associated with an increased rate of weight loss (As long as the diet is calorie reduced). Most of the research I've reviewed have had people eat between 70 and 150 grams of protein per day (not the crazy 250 grams of protein per day suggestions that you find in fitness magazines). If you like, you can definitely try eating a higher protein diet while using Eat Stop Eat.
Q: I'd like to get to single digit body fat, is this the right program for me?
A: Whether your goal is to lose the last 10 stubborn pounds, or the first 10 pounds of your weight loss journey, Eat Stop Eat can and will help you. You can read the chapter 'The Eat Stop Eat lifestyle' for more information on reaching extremely low levels of body fat.
Q: I want to get started right away; do I have to wait for you to deliver my book physically before I get started?
A: Eat Stop Eat will be instantly available for you to download right after your purchase. No shipping fees, no delays, no waiting to get started.
ClickBank is the retailer of products on this site. CLICKBANK® is a registered trademark of Click Sales, Inc., a Delaware corporation located at 917 S. Lusk Street, Suite 200, Boise Idaho, 83706, USA and used by permission. ClickBank's role as retailer does not constitute an endorsement, approval or review of these products or any claim, statement or opinion used in promotion of these products.
Eat Stop Eat Scientific References:
Swinburn B, Sacks G, Ravussin E. Increased food energy supply is more than sufficient to explains the US epidemic of obesity. Am J Clin Nutr 2009; 90:1453-6
Li C, Ford ES, Zhao G, Balluz LS, Giles WH. Estimates of body composition with dual-energy X-ray absorptiometry in adults. Am J Clin Nutr. 2009; 90(6):1457-65
Adams KM, Kohlmeier M, Zeisel SH. Nutrition Education in U.S. Medical Schools: LatestUpdate of a National Survey. Academic Medicine. 2010; 85(9): 1537-1542
Cuneen SA. Review of meta-analytic comparisons of bariatric surgery with a focus on laparoscopic adjustable gastric banding. Surgery for Obesity and Related Diseases. 2008;4: S47-S55.
Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery a systematic review and meta-analysis. Journal of the American Medical Association. 2004; 292:1724-37.
Webber J, Macdonald IA. The cardiovascular, metabolic and hormonal changes accompanying acute starvation in men and women. British Journal of Nutrition. 1994; 71:437-447.
Heilbronn LK, et al. Alternate-day fasting in non-obese subjects: effects on body weight, body composition, and energy metabolism. American Journal of Clinical Nutrition. 2005; 81:69-73
Keim NL, Horn WF. Restrained eating behavior and the metabolic response to dietary energy restriction in women. Obesity Research. 2004; 12:141-149.
Verboeket-Van De Venne WPHG, et al. Effect of the pattern of food intake on human energy metabolism. British Journal of Nutrition. 1993; 70:103-115
Bellisle F, et al. Meal Frequency and energy balance. British Journal of Nutrition. 1997; 77: (Suppl. 1) s57-s70
Gjedsted J, et al. Effects of a 3-day fast on regional lipid and glucose metabolism in human skeletal muscle and adipose tissue. Acta Physiologica Scandinavia 207; 191:205-216
Gardner CD, et al. Comparison of the Atkins, Zone, Ornish, and LEARN diets on change in weight and related risk factors among overweight premenopausal women. The A to Z weight loss study: A randomized trial. Journal of the American Medical Association. 2007; 297(9): 969-998
Hultman E. Physiological role of muscle glycogen in man, with special reference to exercise. Circ Res 1967;20(suppl 1):199-114
Hultman E. Physiological role of muscle glycogen in man, with special reference to exercise. Circ Res 1967;20(suppl 1):199-114
Knapik JJ, Jones BH, Meredith C, Evans WJ. Influence of a 3.5 day fast on physical performance. European Journal of Applied Physiology and Occupational Physiology 1987; 56(4):428-32
Schisler JA, Ianuzzo CD. Running to maintain cardiovascular fitness is not limited by short-term fasting or enhanced by carbohydrate supplementation. Journal of Physical Activity and Health. 2007 Jan;4(1):101-12.
Knapik JJ, Meredith CN, Jones LS, Young VR, Evans WJ. Influence of fasting on carbohydrate and fat metabolism during rest and exercise in men. Journal of Applied Physiology 1998; 64(5): 1923-1929
Nieman DC, et al. Running endurance in 27-h-fasted humans. Journal of Applied Physiology 1987; 63(6):2502-2509
Zinker BA, Britz K, Brooks GA. Effects of a 36-hour fast on human endurance and substrate utilization. Journal Applied Physiology 1990; 69(5): 1849-1855
Aragon-Vargas LF. Effects of fasting on endurance exercise. Sports Med 1993; 16:255-65 26 Gleeseon M, Greenhaff PL, Maughan RJ. Influence of a 24 h fast on a high intensity cycle exercise performance in man. Eur J Appl Physiol Occup Physiol 1988;46:211-19
Dohm, GL, Beeker RT, Isreal RG, Tapscott EB. Metabolic responses to exercise after fasting. Journal of Applied Physiology 61(4): 1363-1368,1986.
Hermansen L, Vaage O. Lactate disappearance and glycogen synthesis in human muscle after maximal exercise. Am J Phsiol 1977; 233:E422-9.
Muthayya S, Thomas T, Srinivasan K, Rao K, Kurpad AV, van Klinken JW, Owen G, de Bruin EA. Consumption of a mid-morning snack improves memory but not attention in school children. Physiology & Behavior. 2007 Jan 30;90(1):142-50.
Green MW, Elliman NA, Rogers, PJ. Lack of effect of short-term fasting on cognitive function. Journal of Psychiatric Research 1995; 29(3), 245-253.
Leiberman HR, Caruso CM, Niro PJ, Adam GE, Kellogg MD, Nindl B, Kramer FM. A double-blind, placebo-controlled test of 2 d of calorie deprivation: effects on cognition, activity, sleep, and interstitial glucose concentrations. American Journal of Clinical Nutrition 2008;88:667–76.
Green MW, Rogers PJ, Elliman NA, Gatenby SJ. Impairment of cognitive performance associated with dieting and high levels of dietary restraint. Physiology and Behavior. 1994;55(3):447-52.
Green MW, Rogers PJ. Impaired cognitive functioning during spontaneous dieting. Psychological Medicine. 1995;25(5):1003-10.
Witte AV, Fobker M, Gellner R, Knecht S, Flöel A. Caloric restriction improves memory in elderly humans. The Proceedings of the National Academy of Sciences. 2009 Jan 27;106(4):1255-60
Bryner RW. Effects of resistance training vs. Aerobic training combined with an 800 calorie liquid diet on lean body mass and resting metabolic rate. Journal of the American College of Nutrition 1999; 18(1): 115-121
Rice B, Janssen I, Hudson, R, Ross R. Effects of aerobic or resistance exercise and/or diet on glucose tolerance and plasma insulin levels in obese men. Diabetes Care 1999; 22: 684-691
Janssen I, et al. Effects of an energy-restrictive diet with or without exercise on abdominal fat, intermuscular fat, and metabolic risk factors in obese women. Diabetes Care 2002; 25:431-438
Chomentowski P, et al. Moderate Exercise Attenuates the Loss of Skeletal Muscle Mass That Occurs With Intentional Caloric Restriction – Induced Weight Loss in Older, Overweight to Obese Adults. Journal of Gerontology: MEDICAL SCIENCES. 2009. Vol. 64A, No. 5, 575–580
Marks BL, Ward A, Morris DH, Castellani J, and Rippe RM. Fat-free mass is maintained in women following a moderate diet and exercise program. Medicine and Science in Sports and Exercise. 1995; 27(9): 1243-51
Gjedsted J, Gormsen L, Buhl M, Norrelund H, Schmitz, Keiding S, Tonnesen E, Moller N. Forearm and leg amino acids metabolism in the basal state and during combined insulin and amino acid stimulation after a 3-day fast. Acta Physiologica. 2009; (6): 1-9.
Gibala MJ, Interisano SA, Tarnopolsky MA et al. (2000) Myofibrillar disruption following acute concentric and eccentric resistance exercise in strength-trained men. Can J Physiol Pharmacol 78, 656–661
Bray GA, Smith SR, De Jonge L, Xie H, Rood J, Martin CK, Most M, Brock C, Manscuso S, Redman LM. Effect of Dietary Protein Content on Weight Gain, Energy Expenditure, and Body Composition During Overeating. JAMA. 2012;307(1):47-55
Deldicque L, De Bock K, Maris M, Ramaekers M, Nielens H, Francaux M, Hespel P. Increased p70s6k phosphorylation during intake of a protein-carbohydrate drink following resistance exercise in the fasted state. Eur J Appl Physiol. 2010 Mar;108(4):791-800.
Samer W. El-Kadi, Agus Suryawan, Maria C. Gazzaneo, Neeraj Srivastava, Renán A. Orellana, Hanh V. Nguyen, Gerald E. Lobley, and Teresa A. Davis. Anabolic signaling and protein deposition are enhanced by intermittent compared with continuous feeding in skeletal muscle of neonates. Am J Physiol Endocrinol Metab 2012;302 E674-E686
Van Proeyen K, De Bock K, Hespel P. Training in the fasted state facilitates re-activation of eEF2 activity during recovery from endurance exercise. Eur J Appl Physiol. 2011 Jul;111(7):1297-305.
Phillips SM, Tipton KD, Aarsland A et al. (1997) Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Physiol 273(1 Pt 1), E99–107.
Rasmussen BB, Tipton KD, Miller SL, Wolf SE, Wolfe RR. An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise. J Appl Physiol. 2000:88;386-392.
Tipton KD, Rasmussen BB, Miller SL, Wolf SE, Owens-Stovall SK, Petrini BE, Wolfe RR. Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise. Am J PhysiolEndocrinol Metab. 2001 Aug;281(2):E197-206.
Burd NA, West DW, Moore DR, Atherton PJ, Staples AW, Prior T, Tang JE, Rennie MJ, Baker SK, Phillips SM. Enhanced amino acid sensitivity of myofibrillar protein synthesis persists for up to 24 h after resistance exercise in young men. J Nutr. 2011 Apr 1;141(4):568-73.
Rogers PJ, Smith HJ. Food cravings and food “addiction”: a critical review of the evidence from a biopsychosocial perspective. Pharmacology biochemistry and Behavior 2000;66(1): 3-14
Lowe MR, Butryn ML. Hedonic hunger: a new dimension of appetite? Physiol Behav 2007; 91: 432–439.
Honma KL, Honma S, Hiroshige T. Critical role of food amount for prefeeding cortcosterone peak in rats.American Journal of Physiology. 1983; 245: R339-R344.
Comperatore CA, Stephan FK. Entrainment of duodenal activity to periodic feeding. Journal of Biological Rhythms. 1987; 2:227-242.
Stephan FK. The “other” circadian system” food as a Zeitgeber Journal of Biological Rhythms. 2002; 17:284-292.
Steffens AB, 1976 Influence of the oral cavity on insulin release in the rat AM J PHysiol 230:1411-1415
Johnstone AM, Faber P, Gibney ER, Elia M, Horgan G, Golden BE, Stubbs RJ. Effect of an acute fast on energy compensation and feeding behaviour in lean men and women. Int J Obes Relat Metab Disord. 2002 Dec;26(12):1623-8.
Guettier JM, Gorden P. Hypoglycemia. Endocrinology Clinics of North America. 2006; 35:753–766
Wiesli P, Schwegler B, Schmid B, Spinas GA, Schmid C. Mini-mental state examination is superior to plasma glucose concentrations in monitoring patients with suspected hypoglycemic disorders during the 72-hour fast. European Journal of Endocrinololgy 2005;152: 605–610.
Alken J, et al. Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals. European Journal of Clinical Nutrition 2008; 62: 721–726
Halaas J, Gajiwala K, Maffei M, Cohen S, Chait B, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269:543–46
Chan JL, et al. Short-term fasting-induced autonomic activation and changes in catecholamine levels are not mediated by changes in leptin levels in healthy humans. Clinical Endocrinology 2007; 66: 49–57
Rosenbaum M, et al. Effects of Weight Change on Plasma Leptin Concentrations and Energy Expenditure. Journal of Clinical Endocrinology and Metabolism 197; 82: 3647–3654
Rosenbaum M, et al. Low dose leptin administration reverses effects of sustained weight reduction on energy expenditure and circulating concentrations of thyroid hormones. The Journal of Clinical Endocrinology & Metabolism 87(5):2391–2394
Ahima RS, Flier JS. Leptin. Annual Review of Physiology. 2000; 62:413-37.
Kolaczynski JW, Considine RV, Ohannesian J, Marco C, Opentanova I, Nyce MR, Myint M, Caro JF. Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves. Diabetes. 1996; 45(11):1511-5.
Brennan AM, Mantzoros CS. Drug insight: the role of leptin in human physiology and pathophysiology: emerging clinical applications in leptin deficient states. Nature Clinical Practice Endocrinology & Metabolism. 2006; 2:318–27.
Hislop MS, Ratanjee BD, Soule SG, Marais AD. Effects of anabolic–androgenic steroid use or gonadal testosterone suppression on serum leptin concentration in men. European Journal of Endocrinology 1999: 141; 40–46
Harle P, Straub RH. Leptin is a link between adipose tissue and inflammation. Annals of the New York Academy of Sciences 2006; 1069: 454-462
Horio N et al. New frontiers in gut nutrient sensor research: nutrient sensors in the gastrointestinal tract: modulation of sweet taste sensitivity by leptin. J Pharmacol Sci. 112(1):8-12. 2010
Baker HWG, Santen RJ, Burger HG, De Krester DM, Hudson B, Pepperell RJ, Bardin CW. Rhythms in the secretion of gonadotropins and gonadal steroids. Journal of Steroids Biochemistry, 1975; 6:793-801.
Habito RC, Ball MJ (2001) Postprandial changes in sex hormones after meals of different composition. Metabolism 50:505–511
Habito RC, Montalto J, Leslie E, Ball MJ (2000) Effects of replacing meat with soyabean in the diet on sex hormone concentrations in healthy adult males. Br J Nutr 84:557–563.
Meikle AW, Stringham JD, Woodward MG, Mcmurry MP (1990) Effects of a fat-containing meal on sex hormones in men. Metabolism 39:943–946.
Volek JS, Gomez AL, Love DM, Avery NG, Sharman MJ, Kraemer WJ (2001) Effects of a high-fat diet on postabsorptive and postprandial testosterone responses to a fat-rich meal. Metabolism 50:1351–1355.
Garrel DR, Todd KS, Pugeat MM, Calloway DH. Hormonal changes in normal men under marginally negative energy balance. Am J Clin Nutr 1984;39:930-936.
Mohr BA, Bhasin S. Link CL, O’Donnell AB and McKinlay JB. The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study. European Journal of Endocrinology. 2006; 155:443-452.
Derby CA, Zilber S, Brambilla D, Morales KH, McKinlay JB. Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study. Clin Endocrinol (Oxf). 2006 Jul;65(1):125-31.
Strain GW, Zumoff B, Miller LK, Rosner W, Levit C, Kalin M, Hershcopf RJ, Rosenfeld RS. Effect of massive weight loss on hypothalamic-pituitary-gonadal function in obese men. J Clin Endocrinol Metab. 1988 May;66(5):1019-23.
Pritchard J, Després JP, Gagnon J, Tchernof A, Nadeau A, Tremblay A, Bouchard C. Plasma adrenal, gonadal, and conjugated steroids following long-term exercise-induced negative energy balance in identical twins. Metabolism. 1999 Sep;48(9):1120-7.
Khoo J, Piantadosi C, Worthley S, Wittert GA. Effects of a low-energy diet on sexual function and lower urinary tract symptoms in obese men. Int J Obes (Lond) 2010;34: 1396–403.
Cangemi R, Friedmann AJ, Holloszy JO, Fontana L, Long term effects of calorie restriction on serum sex hormone concentrations in men. Aging Cell (2010) 9, 236-242
Friedl KE, Moore RJ, Hoyt RW, Marchitelli LJ, Martinez-Lopez LE, Askew EW. Endocrine markers of semistarvation in healthy lean men in a multistressor environment. J Appl Physiol. 2000 May;88(5):1820- 30
Röjdmark S. Influence of short-term fasting on the pituitary-testicular axis in normal men. Hormone Research. 1987; 25(3):140-6.
Bergendahl M, Aloi JA, Iranmanesh A, Mulligan TM, Veldhuis JD. Fasting suppresses pulsatile luteinizing hormone (LH) secretion and enhances orderliness of LH release in young but not older men. J Clin Endocrinol Metab. 1998 Jun;83(6):1967-75.
Klibanski A, Beitins IZ, Badger T, Little R, McArthur JW. Reproductive function during fasting in men. Journal of Clinical Endocrinology and Metabolism. 1981; 53(2):258-63.
Chennaoui M, Desgorces F, Drogou C, Boudjemaa B, Tomaszewski A, Depiesse F, Burnat P, Chalabi H, Gomez-Merino D. Effects of Ramadan fasting on physical performance and metabolic, hormonal, and inflammatory parameters in middle-distance runners. Applied Physiology Nutrition and Metabolism. 2009; 34(4):587-94.
Röjdmark S, Asplund A, Rössner S. Pituitary-testicular axis in obese men during short-term fasting. Acta Endocrinol (Copenh). 1989 Nov;121(5):727-32.
Klibanski A, Beitins IZ, Badger T, Little R, McArthur JW. Reproductive function during fasting in men. J Clin Endocrinol Metab. 1981 Aug;53(2):258-63.
Roemmich JN and Sinning WE. Weight loss and wrestling training: effects on growth-related hormones. J Appl Physiol 82: 1760–1764, 1997.
Friedl KE, Moore RJ, Hoyt RW, Marchitelli LJ, Martinez-Lopez LE, Askew EW. Endocrine markers of semistarvation in healthy lean men in a multistressor environment. J Appl Physiol. 2000; 88(5): 1820–1830.
Bergendahl M, Vance ML, Iranmanesh A, Thorner MO, Veldhuis JD.Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men. J Clin Endocrinol Metab. 1996 Feb;81(2):692-9.
Soeters MR. Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism. American Journal of Clinical Nutrition. 2009; 90:1244–51.
Schteingart DE, Gregerman RI, Conn JW. A comparison of the characteristics of increased adrenocortical function in obesity and Cushing's Syndrome. Metabolism 1963; 1:261-85.
Morton NM. Obesity and corticosteroids: 11beta-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease. Mol Cell Endocrinol 2010; 316: 154-164
Jacoangeli F, Zoli A, Taranto A, et al, 2002 Osteoporosis and anorexia nervosa: relative role of endocrine alterations and malnutrition. Eat Weight Disord 7: 190-195.
Song WO, Chun OK, Obayashi S, Cho S, Chung CE. Is consumption of breakfast associated with body mass index in US adults? J Am Diet Assoc 2005 105(9): 1373-82
Gibson SA, O’Sullivan KR: Breakfast cereal consumption patterns and nutrient intakes of British school children. J R Soc Health 115:336–370, 1995
Shlundt DG, Hill JO, Sbrocco T, Pope-Cordle J, Sharp T. The role of breakfast in the treatment of obesity: A randomized clinical trial. Am J Clin Nutr 1992;55:645-51
Cotton JR, Burley VJ, Blundell JE. Fat and satiety: No additional intensification of satiety following a fat supplement breakfast. Int J Obes, 1992 16(suppl 1): 11
Morgan KJ, Zabik ME, Stampley GL. The role of breakfast in the diet adequacy of the U.S. adult population. J Am Coil Nutr l986;5: 551-63.
Martin A, Normand S, Sothier M, Peyrat J, Louche-Pelissier C, Laville M. Is advice for breakfast consumption justified? Results from a short-term dietary and metabolic experiment in young healthy men. British Journal of Nutrition (2000) 84;337-344
Sarri KO, et al. Greek orthodox fasting rituals: a hidden characteristic of the Mediterranean diet of Crete. British Journal of Nutrition. 2004; 92: 277-284
Sarri KO, et al. Effects of Greek Orthodox Christian church fasting on serum lipids and obesity. BMC Public Health. 2003; 3: 3-16
Neel JV. Diabetes Mellitus: A “thrifty” genotype rendered detrimental by progress”? the American Journal of Human Genetics. 1962; 14:353-362.
Randle PJ, Garland PB, Hales CN, Newsholme EA, The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963:1;785-789.
Halberg N, et al. Effect of intermittent fasting and refeeding on insulin action in healthy men. Journal of Applied Physiology 2005; 99:2128-2136
Klein S, et al. Progressive Alterations in lipid and glucose metabolism during short-term fasting in young adult men. American Journal of Physiology 1993; 265 (Endocrinology and metabolism 28):E801-E806
Soules MR, Merriggiola MC, Steiner RA, Clifton DK, Toivola B, Bremner WJ. Short-Term fasting in normal women: absence of effects on gonadotrophin secretion and the menstrual cycle. Clinical Endocrinology 1994; 40:725-731.
Hosker J, Matthews D, Rudenski A, Burnett M, Darling P, Bown E, Turner R: Continuous infusion of glucose with model assessment: measurement of insulin resistance and b-cell function in man. Diabetologia 28:401–411, 1985
Turner R, Holman R, Matthews D, Hockaday T, Peto J: Insulin deficiency and insulin resistance interaction in diabetes: estimation of their relative contribution by feedback analysis from basal plasma insulin and glucose concentrations. Metabolism 2 8 : 1086–1096, 1979
Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Tu rner R: Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia28:412–419, 1985
Wong MH, Holst C, Astrup A, Handjieva-Darlenska T, Jebb SA, Kafatos A, Kunesova M, Larsen TM, Martinez JA, Pfeiffer AF, van Baak MA, Saris WH, McNicholas PD, Mutch DM; DiOGenes. Caloric restriction induces changes in insulin and body weight measurements that are inversely associated with subsequent weight regain. PLoS One. 2012;7(8):e42858.
Svendsen PF, Jensen FK, Holst JJ, Haugaard SB, Nilas L, Madsbad S. The effect of a very low calorie diet on insulin sensitivity, beta cell function, insulin clearance, incretin hormone secretion, androgen levels and body composition in obese young women.Scand J Clin Lab Invest. 2012 Sep;72(5):410-9.
Mason C, Foster-Schubert KE, Imayama I, Kong A, Xiao L, Bain C, Campbell KL, Wang CY, Duggan CR, Ulrich CM, Alfano CM, Blackburn GL, McTiernan A. Dietary weight loss and exercise effects on insulin resistance in postmenopausal women.Am J Prev Med. 2011 Oct;41(4):366-75.
Kassi E, Papavassiliou AG. Could glucose be a proaging factor? Journal of Cellular and Molecular medicine. 2008; 12(4):1194-8
Ling PR, Smith RJ, Bistrian BR. Acute effects of hyperglycemia and hyperinsulinemia on hepatic oxidative stress and the systemic inflammatory response in rats. Critical Care Medicine 2007; 35: 555-560.
Zechner R, Kienseberger PC, Hammerle G, Zimmermann R, Lass A. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. Journal of Lipid Research 2009;50:3-21.
Nielsen TS, Vandelbo MH, Jessen N, Pedersen SB, Jorgensen JO, Lund S, Moller N. Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue. J Clin Endocrin Metab. 2011;96:E0000-E0000.
Tunstall RJ, et al. Fasting activates the gene expression of UCP3 independent of genes necessary for lipid transport and oxidation in skeletal muscle. Biochemical and Biophysical Research Communications 2002; 294:301-308
Eakman GD, Dallas JS, Ponder SW, Keenan BS. The effects of testosterone and dihydrotestosterone on hypothalamic regulation of growth hormone secretion. J Clin Endocrinol Metab 81: 1217–1223, 1996.
Lang I, Schernthaner G, Pietschmann P, Kurz R, Stephenson JM, Templ H. Effects of sex and age on growth hormone response to growth hormone-releasing hormone in healthy individuals. J Clin Endocrinol Metab 65: 535–540, 1987.
Hartman ML, et al. Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced CH secretion during a two-day fast in normal men. Journal of Clinical Endocrinology and Metabolism 1992; 74(4):757-765
Vendelbo MH, Jorgensen JO, Pedersen SB, Gormsen LC, Lund S, Schmitz O, Jessen N, and Moller N. Exercise and fasting activate growth hormone-dependent myocellular signal transducer and Activator of transcription-5b phosphorylation and Insulin-like growth factor-1 messenger ribonucleic acid expression in humans. Journal of Clinical Endocrinology and Metabolism. 2010; 95(9): 1-5
Rizza RA, Mandarino LJ & Gerich JE. Effects of growth hormone on insulin action in man. Mechanism of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization. Diabetes 1982 31 663–669
Norrelund H. Modulation of basal glucose metabolism and insulin sensitivity by growth hormone and free fatty acids during short-term fasting. European Journal of Endocrinology 2004; 150: 779-787
Hansen M, et al. Effects of 2 wk of GH administration on 24-h indirect calorimetry in young, healthy, lean men. American Journal of Physiology Endocrinology and Metabolism 2005; 289: E1030-E1038
Moller L, Dalman L, Norrelund H, Billestrup N, Frystyk J, Moller N, and Jorgensen JOL. Impact of fasting on growth hormone signaling and action in muscle and fat. Journal of Clinical Endocrinology and Metabolism. 2009;4: 965-972.
Szego CM, White A. The influence of purified growth hormone on fasting metabolism. J Clin Endocrinol Metab 8;1948:594.
Norrelund H. The protein-retaining effects of growth hormone during fasting involve inhibition of muscle protein breakdown. Diabetes 2001;50:96-104
Norrelund H, Rils AL, Moller N. Effects of GH on protein metabolism during dietary restriction in man. Growth hormone & IGF Research 2002; 12: 198-207
Moller N, Jorgensen JO. Effects of growth hormone on glucose, lipid and protein metabolism in human subjects. Endocrine Reviews. 2009; 30:152-177
Norrelund H. Abstracts of Ph.D. Dissertations – Effects of growth hormone on protein metabolism during dietary restriction. Studies in Normal, GH-Deficient and Obese Subjects. Danish Medical Bulletin 2001; 47 (5): 370
Norrelund H. The metabolic role of growth hormone in humans with particular reference to fasting. Growth Hormone and IGF research. 2005;15:95-122.
Oscarsson J, Ottosson M, Eden S. Effects of growth hormone on lipoprotein lipase and hepatic lipase. J Endocrinol Invest 22; 1999: 2-9
Oscarsson J, Ottosson M, Vikman-adolfsson K, et al. GH but not IFG-1 or insulin increases lipprotein lipase activity in muscle tissues of hpophysectomizes rats. J Endocrinol. 160;1999:247-255.
Veldhuis JD, Iranmanesh A, Ho KK, Waters MJ, Johnson ML, Lizarralde G. Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab. 1991 Jan;72(1):51-9.
Cornford AS, Barkan AL, Horowitz JF. Rapid suppression of Growth Hormone concentration by overeating: Potential mediation by hyperinsulinemia. J Clin Endocrinol Metab 96: 824-830, 2011.
Rabinowitz D, Zierler KL. A metabolic regulating device based on the actions of growth hormone and of insulin singly and together in the human forearm 1963. Nature; 199: 913-915.
Veldhuis JD, Roemmich JN, Richmond EJ, Bowers CY. Somatotropic and gonadotropic axes linkages in infancy, childhood, and the pubertyadult transition. Endocr Rev 27: 101–140, 2006.
Veldhuis JD. Aging and hormones of the hypothalamo-pituitary axis: gonadotropic axis in men and somatotropic axes in men and women. Ageing Research Reviews. 2008; 7: 189–208.
Finkelstein JW, Roffwarg HP, Boyar RM, Kream J, Hellman L. Age-related change in the twenty-four hour spontaneous secretion of growth hormone. Journal of Clinical Endocrinolology and Metabolism. 1972 Nov;35(5):665-70
Corpas E, Harman SM, Blackman MR. Human growth hormone and human aging. Endocrine Reviews. 1993; 14: 20–39.
Frayne, K.N. 1993. Insulin resistance and lipid metabolism. Curr. Opin. Lipidol. 4:197–204 156 Boden, G., Chen, X., Ruiz, J., White, J.V., and Rosetti, L. 1994. Mechanism of fatty acid induced inhibition of glucose uptake. J. Clin. Invest. 93:2438–2446.
Kanaley JA, Weatherup-Dentes MM, Jaynes EB, Hartman ML. Obesity attenuates the growth hormone response to exercise. Journal of Clinical Endocrinology Metabolism. 1999;84:3156-3161.
Redman LM, Veldhuis JD, Rood J, Smith SR, Williamson D, Ravussin E; Pennington CALERIE Team. The effect of caloric restriction interventions on growth hormone secretion in nonobese men and women. Aging Cell. 2010 Feb;9(1):32-9.
Rasmussen MH, Hvidberg A, Juul A, et al. Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects. Journal of Clinical Endocrinology Metabolism. 1999; 80:1407-1415
Mauras N, O’brien KO, Welch S, et al. Insulin-like growth factor 1 and growth hormone (GH) treatment in GH-Deficient humans: differential effects on protein, glucose, lipid and calcium metabolism. J Clin Endocrinol Metab 85;2000:1686-1694.
Rennie MJ. Claims for the anabolic effects of growth hormone: a case of the Emperor’s new clothes? British Journal of Sports Medicine 2003; 37:100–105
Duncan GG, Cristofori FC, Yue JK, Murthy MSJ: Control of obesity by intermittent fasts. Med Clin N Amer 48: 1359, 1964.
Johnstone, AM. Fasting – the ultimate diet? Obesity Reviews 2007; 8(3): 211-222
Lionetti L, Mollica MP, Lombardi A, Cavaliere G, Gifuni G, Barletta A. From chronic overnutrition to insulin resistance: the role of fat-storing capacity and inflammation. Nutriton, Metabolism & Cardiovascular disease 2009;19:146-152.
Chung HY, Kim HJ, Kim JW, Yu BP. The inflammation hypothesis of aging: molecular modulation by calorie restriction. Annals of the New York Academy of Sciences. 2001; 928:327-35.
Senn JJ, Klover PJ, Nowak IA, and Moony RA. IL-6 Induces Cellular Insulin Resistance in Hepatocytes. Diabetes. 2002; 51(12):3391-9.
Bharat B. Aggarwal, R.V. Vijayalekshmi, and Bokyung Sung. Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe. Clinical Cancer Research 2009; 15(2): 425-430.
Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. Journal of Clinical Endocrinology and Metabolism. 2004; 89:2548–2556.
Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD, Diehl AM. Leptin regulates proinflammatory immune responses. Federation of American Societies for Experimental Biology Journal. 1998 Jan;12(1):57-65.
Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, Quagliaro L, Ceriello A, Giugliano D. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation. 2002 Oct 15;106(16):2067-72.
Dixit VD. Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span. Journal of Leukocyte Biology. 2008: 84:882-892.
Morgan TE, Wong AM, and Finch CE. Anti-inflammatory mechanisms of dietary restriction in slowing aging processes. Interdisciplinary Topics in Gerontology. 2007; 35:83-97.
Fontana L. Neuroendocrine factors in the regulations of inflammation: Excessive adiposity and calorie restriction. Experimental Gerontology. 2009; 44:41-45.
Prestes J, Shiguemoto G, Botero JP, Frollini A, Dias R, Leite R, et al. Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. Journal of Sports Science. 2009 27(14):1607-1615.
Bruun JM, Helge JW, Richelsen B, Stallknecht B. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. American Journal of Physiology Endocrinology and Metabolism.
2006 May;290(5):E961-7. 176 Schapp LA, Plijm SMF, Deeg DJh and Visser M. Inflammatory markers and loss of muscle mass (Sarcopenia) and strength. 2006. American Journal of Medicine; 199: U82-U90.
Toth MH, Mattews DE, Tracy RP and Previs MJ. Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation. American Journal of Pysiology Endocrinology and Metabolism 2005; 288:E883-E891.
Schoeller, D. A., L. K. Cella, M. K. Sinha, and J. F. Caro. Entrainment of the diurnal rhythm of plasma leptin to meal timing. J. Clin. Invest. 100: 1882–1887, 1997.
Laughlin, G. A., and S. S. C. Yen. Hypoleptinemia in women athletes: absence of a diurnal rhythm with amenorrhea. J. Clin. Endocrinol. Metab. 82: 318–321, 1997
L. K. HILTON AND A. B. LOUCKS Low energy availability, not exercise stress, suppresses the diurnal rhythm of leptin in healthy young women. Am. J. Physiol. Endocrinol. Metab. 278: E43–E49, 2000.
Bourdon, L., A. Buguet, M. Cucherat, and M.W. Radomski. Use of a spreadsheet program for circadian analysis of biological/ physiological data. Aviat. Space Environ. Med. 66: 787–791, 1995.
Grinspoon, S. K., H. Askari, M. L. Landt, D. M. Nathan, D. A. Schoenfeld, D. L. Hayden, M. Laposata, J. Hubbard, and A. Klibanski. Effects of fasting and glucose infusion on basal and overnight leptin concentrations in normal-weight women. Am. J. Clin. Nutr. 66: 1352–1356, 1997.
Visser M, Pahor M, Taaffe DR, Goodpaster BH, Simonsick EM, Newman AB et al. Relationship of interluekin-6 and tumor necrosis factor-a with muscle mass and muscle strength in elderly men ad women” The health ABC study. Journal of Gerontology Series A: Biological Science and Medical Science 2002; 57: M326-M332.
Deter RL, De Duve C. Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes. J Cell Biol 1967;33:437–449
A.M. Cuervo, E. Bergamini, U.T. Brunk, W. Droge, M. Ffrench, A. Terman, Autophagy and aging: the importance of maintaining ‘‘clean’’ cells, Autophagy 1 (2005) 131e140.
T Kanazawa, Ikue Taneike, Ryuichiro Akaishi, Fumiaki Yoshizawa, Norihiko Furuya, Shinobu Fujimura, and Motoni Kadowaki. Amino Acids and Insulin Control Autophagic Proteolysis through Different Signaling Pathways in Relation to mTOR in Isolated Rat Hepatocytes. THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279, No. 9, Issue of February 27, pp. 8452–8459, 2004
Spaulding, S. W., I. J. Chopra, R. S. Sherwin, and S. S. Lyall. Effect of caloric restriction and dietary composition on serum T3 and reverse T3 in man. J. Clin. Endocrinol. Metab. 42: 197-200,1976.
Glynn EL, Fry CS, Drummond MJ, Timmerman KL, Dhanani S, Volpi E, Rasmussen BB. Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr. 2010 Nov;140(11):1970-6.
Joon-Ho Sheen, Roberto Zoncu, Dohoon Kim, David M. Sabatini Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo. Cancer Cell, Volume 19, Issue 5, 613-628, 17 May 2011
Browning, J. D., J. Baxter, S. Satapati, and S. C. Burgess. The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men. J. Lipid Res. 2012. 53: 577–586.
Ding, WX. The emerging role of autophagy in alcoholic liver disease Exp Biol Med 1 May 2011: 546-556.
Hara T, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441:885-9
Komatsu M, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441:880-4
Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self digestion. Nature 2008; 451:1069-75
Alirezaei M, Kiosses WB, Flynn CT, Brady NR, Fox HS. Disruption of neuronal autophagy by infected microglia results in neurodegeneration. PLoS ONE 2008; 3:2906
Wijngaarden MA, Bakker LE, van der Zon GC, 't Hoen PA, Willems van Dijk K, Jazet IM, Pijl H, Guigas B. Regulation of skeletal muscle energy/nutrient-sensing pathways during metabolic adaptation to fasting in healthy humans. Am J Physiol Endocrinol Metab. 2014 Sep 23.
Orvedahl A, Levine B. Eating the enemy within: autophagy in infectious diseases. Cell Death Differ 2009; 16:57-69
Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term fasting induces profound neuronal autophagy. Autophagy. 2010 Aug;6(6):702-10.
Hara, N., K. Nakamura, M. Matsui, A. Yamamato, Y. Nakahara, R. Suzuki-Migishima, M. Yokoyama, K. Mishima, I. Saito, H. Okana, and N. Mizushima. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. In press
Komatsu M, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441:880-4
Jaeger PA, Wyss-Coray T. All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener 2009; 4:16
Harris RBS, Ramsay TG, Smith SR, Bruch RC. Early and late stimulation of ob mRNA expression in meal-fed and overfed rats. J Clin Invest 97: 2020–2026, 1996.
Saladin R, Devos P, Guerremillo M, Leturque A, Girard J, Staels B, Auwerx J. Transient increase in obese gene-expression after food-intake or insulin administration. Nature 377: 527–529, 1995.
Hung SY, Huang WP, Liou HC, Fu WM. Autophagy protects neuron from Aß-induced cytotoxicity. Autophagy 2009; 5:502-10.
Donati A, Cavallini G., Paradiso C., Vittorini S., Pollera M., Gori Z. and E. B. Age-related changes in the autophagic proteolysis of rat isolated liver cells: effects of antiaging dietary restrictions. J Gerontol A Biol Sci Med Sci. 2001; 56: B375-383.
Rubinsztein DC. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature. 2006; 443: 780-786
K. Kirkegaard, M.P. Taylor, W.T. Jackson, Cellular autophagy: surrender, avoidance and subversion by microorganisms, Nat. Rev. Microbiol. 2 (2004) 301e314
B. Levine, Eating oneself and uninvited guests: autophagy-related pathways in cellular defense, Cell 120 (2005) 159e162
Lee MJ, Yang RZ, Gong DW, Fried SK. Feeding and insulin increase leptin translation. Importance of the leptin mRNA untranslated regions. J Biol Chem 282: 72–80, 2007.
Russell CD, Ricci MR, Brolin RE, Magill E, Fried SK. Regulation of the leptin content of obese human adipose tissue. Am J Physiol Endocrinol Metab 280: E399–E404, 2001.
M. Ogawa, C. Sasakawa, Bacterial evasion of the autophagic defense system, Curr. Opin. Microbiol. 9 (2006) 62e68
M.S. Swanson, Autophagy: eating for good health, J. Immunol. 177 (2006) 4945e4951.
Anson RM, et al. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci USA 2003; 100:6216-20
Duan W, et al. Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingting mutant mice. Proc Natl Acad Sci USA 2003; 100:2911-6
Tohyama D, Yamaguchi A and Yamashita T. Inhibition of a eukaryotic initiation factor (eIF2Bdelta/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans. FASEB J. 2008; 22: 4327-4337
Nair U, Klionsky DJ. Activation of autophagy is required for muscle homeostasis during physical exercise. Autophagy. 2011 Dec 1;7(12).
Sandri M. Autophagy in health and disease. 3. Involvement of autophagy in muscle atrophy. Am J Physiol Cell Physiol 2010; 298:C1291-7
Drummond DA. Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution. Cell. 2008; 134: 341-352
Fishebin L, Biological effects of Dietary Restriction. Springer-Verlag, New York.1991.
Lane MA, Ingram DK, Roth GS. Caloric Restriction in nonhuman primates: Effects on Diabetes and cardiovascular disease risk. Toxilogical Sciences 1999; 52s: 41-48.
Varaday KA, Bhutani S, Church EC, Klempel EC, Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults. American Journal of Clinical Nutrition 2009; 90:1138–43.